Haematology and Oncology for UPSC CMS: Anaemia, Leukaemia, Lymphoma, Myeloma and Transfusion

Lymphoma Classification#

Hodgkin: Reed-Sternberg cells (CD15+, CD30+). Nodular sclerosis (young females), Mixed cellularity, Lymphocyte-rich, Lymphocyte-depleted.

Non-Hodgkin:

• B-cell: DLBCL (most common), Follicular, Mantle cell, Burkitt (starry sky), Marginal zone
• T-cell: PTCL-NOS, AITL, ALCL

Multiple Myeloma#

CRAB: hyperCalcemia, Renal insufficiency, Anaemia, Bone lesions (lytic). Serum protein electrophoresis: M-spike. Treatment: Bortezomib + Lenalidomide + Dexamethasone.